The financial toxicity of biotherapeutic treatments is examined. Kymriah, a new gene therapy, has a list price of $475,000 per treatment; Yescarta, from Kite Pharma, costs $373,000 per treatment. Such costs are a significant burden on patients, patients’ families, payers, health care systems, and communities. Studies have shown that financial toxicity—the effect of excessive treatment cost—diminishes patients’ quality of life, compliance, and survival. Some pharmaceutical companies promote outcomes-based pricing and other strategies to offset financial toxicity, but these approaches have not (...) been shown to reduce burdens. Catholic teaching holds that the benefits of treatment should outweigh its burdens, and that burdensome treatments are not obligatory. The financial toxicity of treatments should be included in the ethical assessment of burdens on the patient. (shrink)

Catholic Social Teaching, in considering economic and patient justice, calls for “participating in patient care.” Corporations often are accused of not paying their fair share, which in turn has led to demands for government regulation to lower drug prices in the United States. Meanwhile, the millions of dollars spent by pharmaceutical foundations to help lower-income patients is not seen as corporations’ taking such responsibility to assist patients. The view that CST demands lower costs for prescription pharmaceuticals from corporations that make (...) excess profits misapplies CST principles and does not consider the pricing structure for drugs on a global scale. While a preferential option for the poor is needed, there needs to be a better definition of the poor. This paper looks to broaden the view of CST in regard to corporations and the preferential option for the poor when applied to the current cost of pharmaceuticals. (shrink)

Supporting Hamilton’s inclusive fitness theory, archival analyses of inheritance patterns in wills have revealed that people invest more of their estates in kin of closer genetic relatedness. Recent classroom experiments have shown that this genetic relatedness effect is stronger for relatives of direct lineage (children, grandchildren) than for relatives of collateral lineage (siblings, nieces, nephews). In the present research, multilevel modeling of more than 1,000 British Columbian wills revealed a positive effect of genetic relatedness on proportions of estates allocated to (...) relatives. This effect was qualified by an interaction with lineage, such that it was stronger for direct than for collateral relatives. Exploratory analyses of the moderating role of benefactors’ sex and estate values showed the genetic relatedness effect was stronger among female and wealthier benefactors. The importance of these moderators to understanding kin investment in modern humans is discussed. (shrink)

Terrence Deacon has constructed a tome in which he unleashes his considerable learning in quest of several answers to the question, "What are we?" He is uniquely qualified to take an approach which details the origin and development of, first, language, then the brain, and, lastly, their "co-evolution".

In the worlds of philosophy, linguistics, and communications theory, a view has developed which understands conscious experience as experience which is 'reflected' back upon itself through language. This indicates that the consciousness we experience is possible only because we have culturally invented language and subsequently evolved to accommodate it. This accords with the conclusions of Daniel Dennett (1991), but the 'hermeneutic objection' would go further and deny that the objective sciences themselves have escaped the hermeneutic circle. -/- The consciousness we (...) humans experience is developed only within the context of crossing the 'symbolic threshold' (Percy 1975; Deacon 1997) and one of the earliest and most important symbols we acquire is that of the self, or 'the subject of experience'. It is only when we achieve self-awareness that the world, as such, comes to exist for us as an object (which contains categories and sub-categories of objects). Any consciousness imputed to prelinguistic stages of development is based on projection and guesswork, since we can know nothing directly of it. It can be said that any experience which does not separate an inner subject from an outer world is probably a continuum of sensation in which environmental stimulus and instinctive response are experienced as a unity; it may be 'lived experience' but it is experience 'lived' non-consciously. -/- Speech requires assertion and by learning to speak we find ourselves asserting, in essence, our selves into the world. The narrative form of language allows us to develop life stories, self-knowledge, and, most important, narrative memory coincident with narrative time. All this is made possible with the intersubjective 'net' of language which allows us to know ourselves by first identifying with the viewpoint of others; and, later, such allows us to identify with other minds as we anticipate their reception our communication. These three, assertion, narrative, and intersubjectivity are the essence of what language is and are the keystones that make culture possible outside of nature. (shrink)

La pregunta sobre la muerte sigue siendo una gran preocupación para el hombre de hoy. La concepción bantú-africana de la muerte y el más allá ofrece una original respuesta a este misterio. Presentar la coincidencia y diferencias de dicha original respuestas con otras respuestas posibles será el objetivo de esta reflexión.

Much liberal-democratic thought has concerned itself primarily – even exclusively – with coercive interference in citizens’ lives. But political actors do things – they engage in influential speech, they offer incentives, they mislead other actors, they disrupt the expected functioning of decision-making mechanisms etc. – that fall short of coercion, yet may nonetheless call for normative evaluation and public justification, precisely because they serve to purposively alter citizens’ beliefs, intentions and behaviour. With this article, I explicate a conception of political (...) manipulation to capture this sort of interference, and to distinguish individual manipulation from the manipulation of nonindividual agents like committees, institutions and states. The account, beyond being necessary for further work on the ethics of political manipulation, should prove useful to both normative thinkers interested in power, justice and the ethics of democratic decision-making, and empirical scholars in search of a conceptual apparatus to sharpen their investigations into the exercise of subtle forms of political power. (shrink)

A major aim of the books in this series is to promote psychology's appreciation of the neglected giants in its history. The chapters document the significance of these early contributions, many of them made more than a century ago. Most of the chapters are revisions of invited addresses delivered at psychological conventions. Several of the authors are students, colleagues, or offspring of their pioneers and all of them are intrigued by the life and work of the psychologists about whom they (...) have written. All of the portraits are informal; on occasion, even humorous. Some are "impersonations"--telling stories in what were or might have been the pioneer's own words. This book provides source materials for teachers of undergraduate courses in psychology--particularly the history of psychology--who want to add a personal view in their lectures and offer interesting readings for their students. Each of the five volumes in this series contains different profiles thereby bringing more than 100 of the pioneers in psychology more vividly to life. (shrink)

Georg Lukács (1885-1971) was one of the most original Marxist philosophers and literary critics of the twentieth century. His work was a major influence on what we now know as critical theory. Almost fifty years after his death, Lukács's legacy has come under attack by right-wing extremists in his native Hungary. Despite efforts to erase his memory, Lukács remains a philosophical gadfly. In Confronting Reification, an international team of fourteen scholars explicate, reassess, and apply one of Lukács's most significant philosophical (...) contributions, his theory of reification. Based on papers presented at the 2017 Legacy of Georg Lukács conference held in Budapest, the essays in this volume demonstrate the vitality of Lukács's thought and its relevance. Contributors include: Rüdiger Dannemann, Frank Engster, Andrew Feenberg, Joseph Grim Feinberg, Andraž Jež, Christian Lotz, Csaba Olay, Tom Rockmore, Gregory R. Smulewicz-Zucker, Mariana Teixeira, Michael J. Thompson, Tivadar Vervoort, Richard Westerman, and Sean Winkler. (shrink)

Introduction: -/- It is likely that Boethius (480-524ce) inaugurates, in Latin Christian theology, the consideration of personhood as such. In the Treatise Against Eutyches and Nestorius Boethius gives a well-known definition of personhood according to genus and difference(s): a person is an individual substance of a rational nature. Personhood is predicated only of individual rational substances. This chapter situates Boethius in relation to significant Christian theologians before and after him, and the way in which his definition of personhood is a (...) particular answer to the question, “Jesus has two natures, a divine nature and a human nature, but is one what?” Among Greek (and Syriac) speaking theologians, the typical answer is that Jesus is one ‘hypostasis’. Among Latin speaking theologians, the typical answer is that Jesus is one ‘persona’. It is Boethius’s definition of ‘persona’ that inaugurates personhood as such in Latin speaking theology. Although the Greek and Syriac theologians that I survey come close to a concept of personhood as a distinct category, they do not have such a concept and did not need it for their theological purposes. I show that Rusticus the Deacon is an early witness to this Latin theological invention, and also show that for later Latin theologians, the rationality condition for personhood does very little metaphysical work for their Trinitarian theology or Christology. -/- Further, this chapter surveys Patristic and Medieval Christian theologians’ answers to the question, “God the Father, God the Son, and God the Holy Spirit are one God, but each is one what?” The same replies as above are typically given by Christian theologians. These two theological questions frame the discussion about personhood (and ‘hypostasis’) and put a boundary around what a satisfying account of personhood (and ‘hypostasis’) would be. -/- In contemporary philosophy, there is a lot of attention paid to the rationality condition for personhood. But if we look at the text in which Boethius defines a person, we do not find any precise criteria for it. In other texts, he says that a rational being is one compatible with (capable of) thought and free choice of the will. What we find is that detailed discussion of personhood shows up in theological questions about the Trinity and Incarnation, but not in e.g., applied ethics. The intrusion of personhood into contemporary applied ethics with a focus on detailed and disputed criteria for rationality as a condition for personhood seems to be a modern development. From a Patristic and Medieval Christian theology point of view, trying to find just the right detailed criteria for rationality in order to define personhood is a wild goose chase. This chapter makes clear another contribution that Christian theology had for personhood. Given the theological issues at play in developing a notion of personhood, Christian theologians came to posit that e.g., an individual human is a person contingently (i.e. not essentially), but God the Father, God the Son, and God the Holy Spirit are each a person essentially. The contingency for created persons is not based on whether e.g., an individual human has conscious acts (as might be the case for John Locke) but on the possibility of a divine person’s assuming e.g., an individual human nature. -/- This sampling of Christian intellectual history spans over one thousand years. I make no claim of being exhaustive. The chapter consists of six sections, where each section covers significant historical conversation partners who together represent the sorts of things that Patristic and Medieval Christian theologians where concerned with in theorizing about ‘persona’ or ‘hypostasis’. -/- 1. Origen of Alexandria and the Cappadocians: Basil of Caesarea and Gregory of Nyssa 2. Miaphysites: Severus of Antioch, John Philoponus, and Peter of Callinicum 3. Boethius and Rusticus the Deacon: Rationality, Subsistence, and the Invention of Personhood 4. Neo-Chalcedonians (II): Leontius of Byzantium 5. Scholastic Neo-Chalcedonians (I): Gilbert of Poitiers, Richard of St. Victor, William of Auxerre, Alexander of Hales, Bonaventure, Thomas Aquinas, and William of Ware 6. Scholastic Neo-Chalcedonians (II): Henry of Ghent, John Duns Scotus, and William of Ockham . (shrink)

In the business ethics literature, many argue that managerial decision making ought to be improved by more robust ethical concerns. Some see the virtue of “practical wisdom” as the key for improved managerial decision making. However, because of the epistemic limitations confronting decision makers in the face of irreducible market complexity, there is a risk that practical wisdom, employed in the context of day‐to‐day managerial decision making, becomes an impractical concept. Nevertheless, if the attempt to incorporate virtue ethics (and its (...) related concepts) into business practices is laudable, if indeed a virtuous life is worth pursuing and practical wisdom plays an essential role toward that end, it is important to attempt to salvage practical wisdom and uncover its appropriate usage. Thus, this article pursues two major ends. First, upon surveying some of the prominent and standard usages of the term, it articulates concerns, rooted in epistemic limitations, about the way that practical wisdom appears in business ethics literature. Second, it offers a new way forward for understanding “practical wisdom.” By contextualizing day‐to‐day, rule‐based managerial decision making within the ethical value of the market order, practical wisdom reappears as the higher‐order capacity to pursue vocations, as morally worthwhile projects, in business. (shrink)

Discusses mental processes, the role of humans in nature, experience, and the connection between myth, religion, and science.

This paper argues that Oswald Spengler has an innovative philosophical position on the nature and interrelation of mathematics and science. It further argues that his position in many ways parallels that of Martin Heidegger. Both held that an appreciation of the mathematical nature of contemporary science was critical to a proper appreciation of science, technology and modernity. Both also held that the fundamental feature of modern science is its mathematical nature, and that the mathematical operates as a projection that establishes (...) in advance the manner in which an object will present itself. They also assert that modern science, mathematics and metaphysics all have their roots in the ‘mathematical’, whose essence is itself nothing numerical. (shrink)

Chater & Loewenstein (C&L) ignore the long history by which social scientists have developed more nuanced and ultimately more helpful ways to understand the relationship between persons and situations. This tradition is reflected and advanced in a large literature on “wise” social–psychological or mindset interventions, which C&L do not discuss yet mischaracterize.

ABSTRACT:Although Alasdair MacIntyre has criticized both the market economy and applied ethics, his writing has generated significant discussion within the literature of business ethics and organizational studies. In this article, I extend this conversation by proposing the use of MacIntyre’s account of the virtues to conceive of management as a domain-relative practice that requires and develops practical wisdom. I proceed in four steps. First, I explain MacIntyre’s account of the virtues in light of his definition of a “practice.” Second, I (...) examine his distinction between “practices” and “institutions.” Third, I explain what I mean by a “domain-relative practice” and defend the claim that it is helpful to conceive of management in those terms. Finally, I highlight several features of practical wisdom as a virtue developed in and integral to standards of excellence within management as a domain-relative practice. (shrink)

This study focuses on 22 former students looking for a job or newly entered into the teaching profession. Based on their autobiographical writings, this longitudinal research identifies nine variables influencing their integration. Their weights differ as well as the polarity of their influences. For example, while the steps to get a stable job are often seen as an obstacle, relational skills are an asset for integration into the profession. Moreover, this research suggests, in order to understand these integration processes, that (...) variables beyond classroom work should also be included. (shrink)

Throughout its brief history the philosophy of technology has been largely concerned with the debate over the nature of technology. Typically, technology has been viewed as being essentially another term for applied science, the practical application of scientific theory to the material world. In recent years philosophers and cultural critics have characterised technology in a far more problematic fashion, as an authoritarian power with the ability to bring about far-reaching cultural, political and ecological effects. Proponents of the former view are (...) often termed instrumentalists and those of the latter technological determinists. The debate between them revolves around the question of the fact/value distinction, namely whether technology can be deemed to be value-neutral. I argue that employing a phenomenological approach to technology grants us a fresh perspective on the instrumentalism-determinism debate. It enables us to recast the instrumentalist/determinist debate as a debate between technological idealism and materialism, and to ground the instrumentalist and determinist positions in different experiential relations to technology. It also gives us a better grasp of the function of the different critiques of technology, with idealists concerned primarily with the misapplication of technology as a form of knowledge, and materialists with the existential implications of concrete technological relations. (shrink)

Divine inspiration through the Holy Ghost is topical in the portraits of Gregory the Great: A dove brings him the divine words, which he writes himself or dictates to his deacon Petrus. Thus the charismatic Father of the Church became, like the Evangelists, a divinely inspired medium who transmitted the mandate of spreading the gospel and guaranteed the heavenly origin of the texts that were recited and sung in the liturgy. The preface ‘Gregorius presul’, which is to be (...) found in variant forms introducing antiphonaries and cantatories, states that Gregory, the “powerful teacher” of church chant, composed the songbooks (composuit hunc libellum musicae artis), thereby sanctifying them. Scholars see in this preface a Carolingian strategy of legitimation based on this dynasty’s theocratic concept of power. Gregorian chant, the quintessence of medieval monophonic tradition, has his origins in the Frankish church adopting the “authentic” Roman rite, which was declared canonical liturgy in all churches of the Frankish empire because of Gregory’s authorship. But the consolidation of Gregory’s myth unintentionally legitimated the process of composition, too, because the connection between the concepts of authorship and inspiration justified the composer’s claim to the ministry of spreading the gospel and of attaining the highest knowledge. (shrink)

Man controls and dominates the habitat of most animals, both domestic and wild and there is a need for a pragmatic, workable approach to the problem of reconciling animal welfare with economic forces and the needs of man. It is the author's contention that much of the current philosophical discussion of animal welfare is misdirected now that it is possible to measure to some extent what animals think and feel and how much they can appreciate their quality of life. The (...) book deals with farm animals, pets, wild animals and laboratory animals and dicusses their environmental requirements, fear and stress, their response to pain, injury, disease and death, behaviour and aggression, and the implications of biotechnology and genetic engineering. Finally, the book tries to reconcile reverence for life with the inescapability of killing and reviews the prospects of preserving and enhancing quality of life for animals through legislations, education, economic and moral incentives. (shrink)

Examines modern controversies over Freud and Freudian thought while questioning the theory of infantile sexuality and showing where Freud consistently misdiagnosed his patients and failed to make his claimed cures.